We revisit Jesse’s interview with the delightful stand-up comic Simon Amstell. On TV, he prods at the powers that be and has even caused a few walk-offs. But despite the escapades, Amstell spends much of his time on stage and off looking inward, at himself. The self-doubt got so deep that he went on a shamanic quest to South America for answers. Then Brian K Vaughn talks about his comic book series SAGA. It's a space fantasy about parenting with a deep, engaging mythology. Plus, AV Club contributors Erik Adams and Claire Zulkey talk about some all-time TV favorites: the serial drama Twin Peaks and the British sitcom Spaced. [Portions of this episode previously aired in December 2012.]

We’re talking Veep this week with the HBO comedy’s showrunner, Armando Iannucci, and its star, Julia Louis-Dreyfus. Iannucci talks about geeking out on American and British politics and recreating them on-screen. Then, Louis-Dreyfus talks about her days on Seinfeld and her favorite dirty phrase from Veep. Plus, British singer-songwriter Billy Bragg talks about the song that changed his life.

Jesse talks to the director Shane Carruth. His new movie Upstream Color has almost no dialogue, involves a kind of abstract science fiction premise, but keeps you fully engaged. Then Jesse talks to Rodney Ascher, who directed Room 237. It’s a documentary about The Shining. But it doesn’t go behind the scenes. It features interviews with people who have radical theories about the movie. One guy even says that the film contains signs of a faked moon landing. Rodney and Jesse talk about how plausible all this stuff is, and whether the authorial intent even matters. Plus, comedian Kyle Kinane offers tips on keeping down your cab fare.

Actress Catherine O’Hara talks about her start with the Second City’s SCTV, blockbuster success with Beetlejuice and Home Alone, and her perfect encapsulation of comic absurdity in Christopher Guest films like Waiting for Guffman and A Mighty Wind.

But first, Jesse talks to Big Boi -- one half of OutKast. The hip hop duo swung back and forth across the spectrum of popular music -- zigging with cult favorites like “ATliens”, and zagging with top 40 hits like “The Way You Move”. Plus, pop culture advice from the hosts of My Brother, My Brother and Me.

There’s no mistaking actress Lily Tomlin. Even when the part is small, she’s never lost in the background. In fact she almost steals the show in the new Tina Fey movie. It’s called Admission. Jesse talks to Tomlin about her storied career.  Then astrophysicist Neil deGrasse Tyson chases the unexplored secrets of the universe and then tells Jesse why he shouldn’t be scared of space. Plus, FOUND Magazine’s Davy Rothbart is constantly discovering the amazing notes and photos that other people have left behind. He returns to the program to share a few of his latest favorites.